Here’s what’s in store for you in today’s issue:

🍄 Canadian Senator microdoses for depression

🍄 MindMed’s ibogaine study results

🍄 Yale to study psilocybin for OCD

🍄 Ketamine for gaming addiction 🎮

🍄 And more.

Hear insights from industry experts on the Daily Mushroom Podcast

Listen now on YouTube, Spotify, or Apple

inspirational banner

Canadian Senator microdoses for depression

In his opening speech at the Catalyst Psychedelics Summit, Canadian Senator Larry Campbell shared his fascinating (yet slightly disturbing) experience with microdosing.

The 74-year-old politician had been suffering from depression and PTSD for ages when his mental health suddenly started improving out of nowhere.

When Larry told his wife the good news, she admitted that she’d been spiking his morning coffee with a bit of psilocybin for the past two weeks 😲

While we don’t condone drugging people without their knowledge, her experiment revealed some important anecdotal evidence – the benefits that Larry experienced must have been from the psilocybin itself and not a result of the placebo effect!

Group ketamine therapy now available for frontline workers

After piloting the program for 9 months, Novamind’s group ketamine therapy for frontline workers is now available to the public.

The 6-week program is designed to help healthcare workers, police officers, firefighters and paramedics work through trauma with the support of their peers.

“The greatest improvement has been my PTSD… Even when I do feel myself reacting, I feel I have more awareness and I am able to better regulate,” says one of the participants of the pilot program. 

Therapeutic banner

MindMed advances ibogaine research after successful Phase 1 trial

This quarter, MindMed (MNMD) will begin a Phase 2a trial to see if its non-hallucinogenic ibogaine formulation (MM-110) can treat opioid withdrawal.

In preclinical research, MM-110 showed “multi-day reductions in opioid self-administration” after a single dose. 

In the Phase 1 trial, MM-110 was found to be safe and well-tolerated at varying doses. Some participants received two 325 mg doses on a single day while others received a 90 mg dose twice daily for 7 days.

Let’s see what Phase 2 reveals!


Yale to study psilocybin for OCD

Ceruvia Lifesciences submitted an application to study psilocybin as a treatment for obsessive-compulsive disorder (OCD) in a Phase 2 trial.

Preliminary findings suggest that psilocybin causes a “rapid and robust improvement in OCD symptoms with a sustained effect,” according to the press release.

The trial, which will be led by Yale researchers later this year if approval is granted, will determine if these findings hold true when psilocybin is compared to an active placebo. 


“Hugely encouraging” ketamine study 🎮

Collectively, over a billion people struggle with Gambling Disorder, Internet Gaming Disorder, Binge Eating Disorder, and Compulsive Sexual Behaviour.

Researchers at Awakn Life Sciences (AWKN) completed the world’s first ketamine study for these behavioural addictions. The results were “hugely encouraging,” according to the CEO. 

While actual data is yet to be released, the promising early findings “merit a larger study and further exploration,” which the company is now pursuing.

business banner

Silo Pharma (SILO) began a trial to see if psilocybin can reduce inflammation in patients with signs of Parkinson’s disease.

Beckley Psytech will be using Empatica’s wearable biomarker devices in a 5-MeO-DMT study for treatment resistant depression. The devices will gather behavioural and physiological data with the goal of identifying early signals of patient response and relapse.

Braxia Scientific (BRAX) received Health Canada approval to administer psilocybin therapy for depression through the Special Access Program.

CB Therapeutics was granted a patent for an “eco-conscious” psilocybin production method involving precision fermentation.

PharmaTher (PHRM) is partnering with CC Biotechnology to develop a wearable ketamine delivery device for mental health, chronic pain, and neurological disorders. 

legal banner

Oregon finalizes rules for psilocybin program

The Oregon Health Authority has finalized the first subset of rules for the legal psilocybin services that will be available next year.

The full set of guideline, which cover psilocybin production methods and facilitator training requirements, can be found here.

A second committee meeting will take place in the Fall to establish the remainder of the rules.

You’re all caught up! See you next Wednesday 👋