XPhyto Announces New Director of Business Development and Head of Diagnostic Research

XPhyto Announces New Director of Business Development and Head of Diagnostic Research

Vancouver, Canada, and Uttenweiler, Germany (January 10, 2022) – XPhyto Therapeutics Corp. (CSE:XPHY / OTC:XPHYF / FSE:4XT) (“XPhyto” or the “Company”) is pleased to announce two key appointments to continue its focus on research, development and commercialization of its biosensor and diagnostic products including for the detection of COVID-19.

Director of Business Development

Mr. Roland Spleiss has joined as the Director of Business Development. Mr. Spleiss is a seasoned commercial professional with over 25 years of experience in planning and building out effective salesforces, strategic realignment, production relocation, and project management, which makes him ideally suited to drive product sales.

In addition to extensive consulting roles, Mr. Spleiss held senior positions including Chief Financial Officer of Wörwag Pharma, a private German health and generic pharmaceutical company with over EUR 200 million in annual sales and 900 employees. He led the company’s strategic professionalization and internationalization of operations, optimization of supply chains and sales processes, and expansion into new European, Asian and Latin American healthcare markets.

Mr. Spleiss’ expertise in production and supply chain management, cost optimization, and sales force and distribution network creation will be invaluable to XPhyto’s commercial strategy and execution.

Head of Diagnostic Research

Dr. Heinrich Jehle has joined XPhyto as Head of Diagnostic Research. Dr. Jehle has over 20 years’ experience in the research and development of innovative medical screening tests and diagnostics. Previously, Dr. Jehle held senior roles in project management and research & development at leading European biotech and diagnostics companies.

More recently, Dr. Jehle co-founded 3a-diagnostics GmbH as managing director where he led the development of the first saliva activated “in-mouth” biosensor candidates to identify active pathogens in the saliva and built a portfolio of innovative diagnostics biosensor products. The enzyme-activated biosensors are developed for real-time, low-cost and easy-to-use oral screening applications for the rapid detection of infectious diseases including COVID-19 at home or at the point-of-care.

“Mr. Spleiss and Dr. Jehle are tremendous additions to the XPhyto team,” said Prof. Dr. Thomas Beckert. “Mr. Spleiss brings robust knowledge and experience in the development of product sales and economic optimization with a demonstratable track record of success. Dr. Jehle’s scientific expertise ensures the continued advancement and commercialization of innovative biosensor and diagnostic products, which is a key component of XPhyto’s short- and long-term success.”

XPhyto is pleased to have embarked on a recent process of rapid and transformative leadership change and organizational optimization.

The Company is not making any express or implied claims that its product has the ability to eliminate, cure or contain the COVID-19 pandemic.

XPhyto Epilepsy clinical trial planned in 2022 with its proprietary fast-dissolving CBD oral strips

XPhyto Epilepsy clinical trial planned in 2022 with its proprietary fast-dissolving CBD oral strips

Vancouver, Canada, and Uttenweiler, Germany (December 15, 2021) – XPhyto Therapeutics Corp. (CSE:XPHY / OTC:XPHYF / FSE:4XT) (“XPhyto” or the “Company”) is pleased to provide an update on the development of its fast-dissolving CBD oral strips. With significant complexities involved in the planning and preparation for the pending human pilot study, the Company is pleased to announce that its European human CBD bioavailability study will commence in January 2022.

Prof. Dr. Beckert said, “the clinical trial of our CBD product is aiming to demonstrate the efficient and precise dosing of the treatment. If successful, this could make a significant difference to Epilepsy patients and we are excited to commence the trial next year.”

XPhyto is developing a hybrid-generic CBD prescription drug formulation that employs the Company’s proprietary oral dissolvable (“ODF”) platform to deliver precise and efficient CBD dosages for the treatment of certain forms of childhood Epilepsy.

The US Food & Drug Administration (FDA) and European Medicines Agency (EMA) have approved CBD based medical products from other companies for the treatment of severe childhood forms of Epilepsy, including Dravet syndrome and Lennox-Gastaut syndrome. The currently approved and registered formulation of CBD is a lipophilic solution in sesame oil with a standard dosage of 750 mg/day. Due to low bioavailability (approximately 5%) the formulation could be considered highly inefficient compared to the XPhyto ODF platform.

For the purpose of carrying out XPhyto’s clinical study, the following important and necessary items have been completed or received: Product Development Report, Investigational Medicinal Product Dossier, Permit for Clinical Study, manufacture of clinical product samples; Product Specification File; monitoring agreement; and Import Authorization to the location of the FDA-inspected Clinical Research Center. Pending success in the CBD pilot study, the Company expects to carry out a pivotal clinical study in 2H of 2022.

The Company’s CBD-based Epilepsy treatment program is one of several dissolvable oral drug delivery programs. Oral thin film drug delivery is a large and growing international industry which provides an alternative to conventional solid and liquid oral dosage forms. Transparency Market Research estimates that the global market for thin film drug manufacturing will be worth US$15.98 billion by 2024, rising at a 9.0% CAGR between 2019 and 2024. XPhyto’s additional oral thin film drug delivery programs include both cannabinoid and non-cannabinoid products for pain, neurology, and infectious disease. The Cannabidiol Market revenue is estimated to be worth over US$89 billion by 2026 according to Global Market Insights Inc.

Executive management of XPhyto’s drug formulation business is led by Prof. Dr. Beckert, managing director of Vektor Pharma TF GmbH. Prof Dr. Beckert is a German-based scientist and experienced corporate executive who is leading XPhyto’s drug formulation and diagnostics operations.

XPhyto Completes Strategic Acquisition of 3a-diagnostics GmbH

XPhyto Completes Strategic Acquisition of 3a-diagnostics GmbH

  • The acquisition positions XPhyto to be a leading Biosensor producer integrating thin film technology with 3a-diagnostics biosensor technology
  • The acquisition of 3a, a German-based rapid point-of-care diagnostics firm adds IP and a deeply experienced scientific expertise to XPhyto
  • Gains technical and business synergies
  • Secures XPhyto a near-term infectious disease biosensor portfolio and related Intellectual Property

Vancouver, Canada, and Uttenweiler, Germany (December 6, 2021) – XPhyto Therapeutics Corp. (CSE:XPHY / OTC:XPHYF / FSE:4XT) (“XPhyto” or the “Company”) is pleased to announce that the acquisition of 3a-diagnostics GmbH (“3a”), first announced July 20, 2021, is now complete.

“The strategic acquisition of 3a is a transformative step in XPhyto’s commercial strategy,” said Peter Damouni, XPhyto director. “The integration of a highly innovative European biosensor development company places XPhyto at the forefront of the rapid point-of-care test industry, an explosive and technology driven sector. This transaction is the second acquisition since going public in August 2019. XPhyto completed the takeover of Vektor Pharma TF GmbH in September 2019. The corporate strategy of acquiring high-tech biotechnology and pharma companies showcases the potential growth acceleration and synergies for XPhyto’s biosensors, diagnostics and drug delivery portfolios.”

3a is a research-based biotechnology company located Southeast of Stuttgart, Germany, specializing in the development, production and marketing of point-of-care (PoC) test systems. 3a has developed and patented a pipeline of oral biosensor screening tests for bacterial and viral infectious diseases, including stomatitis, periimplantitis, periodontitis, group A strep, and influenza A. The company has developed a high-throughput biosensor screening platform for rapid identification of new biosensor targets. 3a has also received grant funding from the German Federal Ministry of Education and Research for the development of real-time, low-cost and easy-to-use oral screening tests for the rapid detection of influenza A variants that are high-risk pandemic threats such as H1N1 and H5N1.

3a’s COVID-19 portfolio includes “Covid-ID Lab” a rapid point-of-care PCR test platform with a CE mark approved for sale in Europe. Total processing time is 25 minutes with minimal equipment and training. On July 28, 2021, XPhyto and 3a announced the identification of the first saliva activated “in-mouth” biosensor candidates for the detection of a COVID-19 infection. This research is the foundation for the development of the first enzyme-activated biosensors for real-time, low-cost and easy-to-use oral screening applications for the rapid detection of COVID-19.

The Company has recently received an EU commercial registration number to sell its biosensor for mouth related infections and oral inflammation, announced August 30, 2021. This product has application for the global oral health and cosmetic dentistry market. The Global Dental Services Market is expected to be $435 billion in 2021 according to MedicalExpo e-magazine and projected to reach $698.8 billion by 2030 and is growing at a CAGR of 6.4% according to Precedence Research.

“With the integration of 3a’s biosensor technology into our next-generation ODF platform, we are excited to be positioned to transform and dominate the market for rapid screening tests for a wide range of infectious diseases, including COVID-19, with highly affordable rapid oral tests starting in the coming year,” says Prof. Dr. Thomas Beckert, Managing Director of Vektor Pharma TF GmbH, a wholly owned subsidiary of XPhyto. He adds, “we have several biosensors in the development pipeline and plan to enter the market with low-cost rapid tests for infectious diseases, for which there are currently no rapid tests available, as early as 2022. We are very confident and excited to have the opportunity to revolutionize the diagnostics and rapid test market with products based on our integrated proprietary technologies, that are unique and leading in the world.”

The acquisition of 3a is projected to produce significant synergies in research and development and manufacturing; significantly improved margins for commercial products, such as Covid-ID Lab; as well as expedite commercialization of products in 3a’s near-market development pipeline. 3a’s intellectual property, including patents, know-how, expertise and contracts are included in the acquisition.
Executive management of 3a will be led by Prof. Dr. Beckert, managing director of Vektor Pharma TF GmbH. Prof Dr. Beckert is a German-based scientist and experienced corporate executive who is leading XPhyto’s drug formulation and diagnostics operations.
The Company is not making any express or implied claims that its product has the ability to eliminate, cure or contain the COVID-19 pandemic.

XPhyto Therapeutics Closes Private Placements for Gross Proceeds of $7,000,0000

XPhyto Therapeutics Closes Private Placements for Gross Proceeds of $7,000,0000

NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES

VANCOUVER, BC – November 26, 2021 ‐ XPhyto Therapeutics Corp. (“XPhyto” or the “Company”) (CSE:XPHY / OTC:XPHYF / FSE:4XT) is pleased to announce that further to its news release dated November 3, 2021, it has now closed its $1.00 common share non-brokered private placement (the “Equity Offering”), as well as its previously announced non-brokered convertible debenture unit offering (the “Debenture Offering”).

The Equity Offering resulted in the distribution of 4,500,000 common shares of the Company (a “Share”) for gross aggregate proceeds of $4,500,000. The Debenture Offering resulted in gross aggregate proceeds of $2,500,000 through the issuance of $2,500,000 in principal, convertible into Shares at a conversion price of $1.25 per Share, and 2,000,000 Share purchase warrants, exercisable into Shares at an exercise price of $1.50 for a period of 2 years.

The Debenture will mature and be repayable on the date that is 2 years from the closing date, and bear interest at a rate of 8% per annum until maturity, which will be calculated and payable semi-annually on the last day of June and December in each year. The terms of the Debentures further provide that the Company may from time to time, at the Company’s option, prepay all or part of the principal amount plus accrued and unpaid interest without penalty or bonus. Conversion of the Debentures may be forced at the option of the Company if the 15-day volume weighted average price of the Shares on the Canadian Securities Exchange exceeds 250% per share of the exercise price.

In consideration for the services of an eligible finder who introduced subscribers to the Company for the completion of the Equity Offering, the Company issued 360,000 common share purchase warrants, exercisable at $1.11 into common shares of the Company for a period of 24 months from closing, and paid cash commissions aggregating $360,000 to such finders. The eligible finder that introduced the subscriber to the Company for purpose of completing the Debenture offering received 160,000 common share purchase warrants, exercisable at $1.25 into common shares of the Company for a period of 24 months from closing, and were paid $200,000 in cash commission.

The CFO of the Company (the “Insider”) participated in the Equity Offering by purchasing a total of 25,000 Shares. The Issuance of the securities to the Insider pursuant to the Equity Offering is considered to be a “related party transaction” subject to Multilateral Instrument 61-101 Protection of Minority Security Holders in Special Transactions (“MI 61-101”). The Company intends to rely on exemptions from the formal valuation and minority shareholder approval requirements provided under sections 5.5(a) and 5.7(a) of MI 61-101 as neither the fair market value (as determined under MI 61-101) of the subject matter of, nor the fair market value of the consideration for, the transaction, insofar as it involves interested parties, exceeded 25% of the Company’s market capitalization.

The Company intends to use the proceeds from each of these private placements to complete its previously announced acquisition of 3a-diagnostics GmbH, as well as for corporate development and general working capital purposes. For further information related to the acquisition of 3a-diagnostics GmbH, please see the Company’s news release dated November 3, 2021.

All securities issued or issuable in connection with closing of the Equity Offering and the Debenture Offering will be subject to a statutory hold period of four months plus a day from the date of issuance in accordance with applicable securities legislation, expiring March 26, 2022.

XPhyto Announces Managing Director Appointment, Financing and 3a-diagnostics Development

XPhyto Announces Managing Director Appointment, Financing and 3a-diagnostics Development

NOT FOR DISTRIBUTION TO UNITED STATES NEWS WIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES

Vancouver, Canada, and Uttenweiler, Germany (November 3, 2021) – XPhyto Therapeutics Corp. (CSE:XPHY / OTC:XPHYF / FSE:4XT) (“XPhyto” or the “Company”) is pleased to announce the appointment of Prof. Dr. Thomas Beckert as the managing director of XP Diagnostics GmbH, a 100% owned subsidiary of XPhyto.

With the next phase of growth and development, Prof. Dr. Thomas Beckert will be appointed to the position of managing director of XP Diagnostics GmbH to run XPhyto’s operations in Germany and to oversee the integration of 3a-diagnostics GmbH (“3a”). Prof. Dr. Beckert is a world-renowned expert in thin film drug delivery systems and the managing director of Vektor Pharma TF GmbH, a 100% XPhyto owned German drug manufacturer, developer, and research organization located in the district of Biberach, Baden-Württemberg, Germany. His expertise includes formulation and machine development for transdermal and oral dissolvable therapeutic systems. For over a decade, Prof. Dr. Beckert and his team have been leaders in the design, testing and manufacture of thin film drug formulations, particularly transdermal patches and sub-lingual (oral) strips for the delivery of active pharmaceutical ingredients for the treatment of pain and neurological indications.

Wolfgang Probst, previously COO of XPhyto, will continue as a Director of XPhyto Therapeutics Corp. This strategic change allows for the Company’s transition and integration of 3a-diagnostics GmbH.

Hugh Rogers stated, “We are extremely pleased with this appointment of Prof. Dr. Thomas Beckert as Managing Director. He, along with his team, will ensure the seamless integration of 3a-diagnostics and the development of the Company’s novel biosensor. 3a’s innovative biosensor system in particular, is a promising and reliable platform technology for accurate, early screening and diagnosis of diseases. This strategically combines Vektor Pharma’s thin film technology and 3a-diagnostics Biosensors to create a novel and exciting product pipeline.

The Company will also launch a non-brokered private placement of common shares (the “Offering”) and unsecured convertible debentures (the “Debentures”). Pursuant to the Offering, the Company has arranged a non-brokered private placement of up to 5,000,000 common shares of the Company (the “Shares”) at a price of $1.00 per Share for total gross proceeds of up to $5,000,000.

The Company has arranged the issue of up to $2,500,000 of unsecured convertible debentures and 2,000,000 common share purchase warrants (the “Warrants”). The Debentures will bear interest from the date of issuance at a rate of 8.0% per annum, payable semi-annually, and will mature on the date that is two years from the date of issuance. The principal amount of the Debentures is convertible at the option of the holder into common shares in the capital of the Company (the “Common Shares”) at any time prior to the Maturity Date at a conversion price of $1.25 per Common Share. Conversion of the Debentures may be forced at the option of the Company if the 15-day volume weighted average price of the Common Shares on the Canadian Securities Exchange exceeds 250% per share of the exercise price. Each Warrant is exercisable by the holder into one common share of the Company at a price of $1.50 per share for a period of two years from the date of issuance.

The Company intends to use the net proceeds of the Offering and Debentures for research and development, inventory purchases, general working capital purposes, and to complete the acquisition of 3a, as first announced July 20, 2021 (the “Acquisition”). Further to the Acquisition agreement between XPhyto and 3a, the parties have agreed to extend the closing terms which is expected to complete on or around December 1, 2021.

Completion of the Offering and Debentures is subject to the satisfaction of certain conditions, including notice to the CSE. The securities issued pursuant to the Offering will be subject to a statutory four month hold period. Finder’s fees will be paid in connection with the Offering pursuant to applicable CSE policies and Canadian securities regulations.