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Docs on Mushrooms: issue 32

Hello and welcome back.

We’re excited to announce that we’ll be bringing you a FREE virtual event on February 3rd to discuss all things psychedelic and mental health. If your New Year’s resolution is to work on your mental health, you won’t want to miss it! Keep reading for details 😊

Here’s what’s in store for you in today’s issue:

🍄 The most intense psychedelic?

🍄 Impressive findings from a ketamine study on addiction

🍄 A promising treatment for ALS

🍄 Rescheduling psilocybin GLOBALLY

🍄 And more.

Be sure to check out this week’s Daily Mushroom podcast:

What physicians really think about psilocybin

On this episode of the Daily Mushroom Podcast, we have Dr. Lyle Oberg, co-founder, and CEO of MYND life sciences. Dr. Oberg has been had an extensive career across many sectors, including working as a family physician and a Chief Policy and Medical Officer at a cannabis company. He was also part of the Alberta government for 15 years as Minister of Finance, Social Services, Learning, and more. Stick around to hear what Dr. Oberg has to say, we are sure it will give a new insight into the world of psychedelics!

Therapeutic banner

86% abstinent after ketamine therapy

Six months after receiving three ketamine infusions and Awakn Life Sciences’ proprietary therapy, 86% of patients with severe alcohol use disorder remained abstinent from alcohol. 

Awakn’s study also showed that:

  • The treatment was 2.7x more effective than placebo infusions and alcohol education
  • Risk of mortality within one year dropped from 1 in 8 patients to 1 in 80
  • Liver function improved (shocker)
  • Depression scores were significantly reduced
  • Ability to experience pleasure increased

The downside? There isn’t one. There were no serious adverse reactions either 👏

Slowing the progression of ALS

When diagnosed with ALS, patients are typically given 2 to 6 years to live and experience rapid decline in muscle function. Even after the ice bucket challenge took the internet by storm, a cure has yet to be found. 

Luckily, ketamine is showing potential to slow the progression of the disease to improve both the quality and length of patients’ lives.

In a mouse model of ALS, PharmaTher (PHRM) found that ketamine preserved muscle function and increased life expectancy if administered in the early stages of the disease. 

The company received FDA approval for a Phase II trial that will assess a biomarker of neurodegeneration, functional abilities, muscle strength, and depression scores among ALS patients undergoing ketamine treatments.

Psilocybin + CBD 🧠

The majority of patients with traumatic brain injury (TBI) also experience depression, and patients with severe TBI-related depression are 5x more likely to attempt suicide.

Wesana Health (WESA) is planning a study to see if the condition can be treated with one large dose of psilocybin in a clinic, followed by “self-administered maintenance doses” of psilocybin and CBD to sustain the benefits.

Researchers believe the treatment will promote neuroplasticity and neurogenesis while reducing neuroinflammation.

Can ketamine enhance addiction medication?

Novamind (NM) is hosting a first-of-its-kind study to find out.

The trial will see if ketamine-assisted therapy can enhance the effectiveness of buprenorphine, a first-line addiction medication, in treating opioid use disorder. 

Will the two drugs finally be able to conquer this treatment-resistant condition?

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Join our virtual Mental Health Town Hall

We’re collaborating with experts at Entheon Biomedical (ENBI) to bring you a special virtual event on February 3rd. 

Here’s what you can expect to learn:

  • The latest psychedelic research on mental health and addiction
  • How psychedelics can be used for personal development
  • All things microdosing
  • Where the industry is headed
  • Answers to all your burning questions

You’ll hear insights and stories from:

  • Timothy Ko, CEO and Founder of Entheon
  • Dr. Andrew Greenshaw, Scientific Advisor to Entheon and Professor of Psychiatry and Neuroscience at the University of Alberta
  • David Mayoh, Communications Manager at Entheon
  • Thomas Hartle, the first Canadian to receive psilocybin therapy
  • And more

Now is your chance to get your questions answered by industry experts and connect with fellow members of the Daily Mushroom Community. We can’t wait to see you there. Register now 👇

The most intense psychedelic?

“​​I truly doubt that there is another psychedelic drug, anywhere, that can match [4-HO-DiPT] for speed, intensity, brevity, and sensitive to dose, at least one that is active orally.”

Field Trip Health’s (FTRP) first novel compound could produce the most intense experience of any oral psychedelic. 

It’s a more stable and soluble version of 4-HO-DiPT — a drug that induces an extremely powerful experience lasting 2-3 hours, according to Alexander Shulgin, the chemist who created it.

Considering he’s experimented with 55 different psychedelics, which he reviewed in “Tryptamines I Have Known and Loved,” we’ll take his word for it. 

Field Trip expects to receive a patent for the formulation next month. 

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Mydecine (MYCO) is launching a program to sell MDMA and psilocybin, as well as training and support services, to healthcare practitioners through Health Canada’s amended Special Access Program. The company also completed a model that can rapidly screen billions of compounds using AI to find novel psychedelics that bind to serotonin receptors. 

Delic Holdings Corp. (DELC) announced that it plans to more than double its footprint in the next 18 months by opening 15 new ketamine clinics, which will be strategically located in secondary cities to improve patient accessibility.

Ketamine One (MEDI) began trading on the OTCQB marketplace under the symbol ‘KONEF’.

atai Life Sciences (ATAI) received FDA approval for a study to investigate how its R-ketamine compound interacts with other drugs.

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Rescheduling psilocybin GLOBALLY 🌍

“Given today’s scientific understanding of psilocybin’s high potential therapeutic value and low risk of dependence, a change of its status as a Schedule I drug is long overdue,” according to Christopher Koddermann.

That’s why he co-founded The International Therapeutic Psilocybin Rescheduling Initiative (ITPRI) – an initiative that’s pushing for psilocybin to be rescheduled on a global scale.

ITPRI aims to reschedule psilocybin through the United Nations’ Convention on Psychotropic Substances, which was enacted over 50 years ago 😮 This would significantly reduce the regulatory barriers that impede psilocybin research and access to treatment.

So yes, rescheduling is long overdue, but better late than never!

Plus, progress in the US & Italy:

  • A Missouri Rep. filed a bill to expand the state’s right-to-try law to include psilocybin, MDMA, DMT, ibogaine, LSD, mescaline, and peyote. This would grant patients with serious illnesses legal access to the substances. Read more…

  • Senator Scott Wiener announced that he is once again pushing for a psychedelic decriminalization bill in California after halting it last year, and believes it has a 50/50 chance of being passed. To generate support, veterans are meeting with Assembly members and changes may be made to possession limits and types of psychedelics included. Read more…

  • Virginia lawmakers introduced a bill to reduce the penalty for possessing peyote, ibogaine, psilocybin, or psilocin from a Class 5 felony to a $100 fine. A separate bill focused on just psilocybin and psilocin was also filed. Read more…

  • Italian officials verified 630,000 signatures collected in support of a measure to decriminalize cultivation of marijuana and psilocybin mushrooms. If the measure is approved by the Constitutional Court, which will be announced on February 15, it will appear on a ballot this spring. Read more…

Turning mushrooms into mush houses

Architect David Benjamin wants to make the construction industry more sustainable using (you guessed it) mushrooms!

He constructed a 40-foot-tall structure using bricks grown from mushroom mycelium. 

The bricks are lightweight yet durable and can be grown in five days without emitting carbon or producing waste.

Video of the Week

The Battle Over Psychedelic Therapy’s Future

Playlist of the Week

Trippy Songs 🍄🍃👽🚀
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Wesana Health Provides Strategic and Operational Updates

Wesana Health Provides Strategic and Operational Updates

  • Wesana granted pre-IND meeting with FDA, currently set for March 11, 2022
  • Wesana Clinics exhibited a record quarter of billings, new patient visits, telemedicine utilization, overall patient appointments, and ketamine administrations
  • New flagship clinic set to open in late Q1 2022 showcasing the service evolution of Wesana Clinics
  • Strategic restructuring program to realize $1.1M in general corporate overhead reduction and improve operational efficiencies

CHICAGO and TORONTO, Jan. 12, 2022 (GLOBE NEWSWIRE) — Wesana Health Holdings Inc.  (“Wesana” or the “Company”) (CSE: WESA; OTCQB: WSNAF), a data driven life sciences company focused on developing the novel therapies of tomorrow and delivering new care paradigms today, is pleased to announce the following strategic and operational updates to the Company’s Care Development and Care Delivery businesses in addition to leadership changes as the Company streamlines its strategy going into FY 2022.

Care Development

Program overview

Wesana’s drug development program looks to utilize combination therapy to treat the symptoms associated with Traumatic Brain Injury (“TBI”), such as depression and anxiety, and migraines. By utilizing psilocybin and cannabidiol (“CBD”), a combination therapy of compounds with demonstrated effectiveness, Wesana’s lead drug candidate, SANA-013, is targeted to improve neuroplasticity and neurogenesis while acting as an anti-neuroinflammatory. In contrast to therapist assisted, single dose therapy, where a large dose of psilocybin is administered in clinic, which has exhibited poor durability and waning effects over a short time-period, SANA-013 utilizes a loading dose of psilocybin in combination with self-administered at-home maintenance doses of psilocybin and CBD to provide more sustained effects and benefit over time.

Pre-IND meeting milestone

The U.S Food and Drug Administration (“FDA”) granted the Company’s request for a pre-Investigational New Drug (“IND”) meeting to discuss the novel therapy and proprietary protocol of SANA-013 for the treatment of TBI-related major depressive disorder (“MDD”).

In the pre-IND meeting, scheduled for March 11, the Company expects to receive feedback from the FDA on its toxicology program and research to-date. The outcome of the meeting will provide key development guidance in advance of IND clearance and initiation of the Phase I clinical trial, currently anticipated to occur in late 2022.

Mark Wingertzahn, Chief Scientific Officer of Wesana commented: “We are impressed with the latest Wesana data and look forward to discussing our drug development approach with regulators in the US and abroad.”

Care Delivery

Record Q4 numbers at Wesana Clinics

The Company is pleased to report that following its previously announced milestone of 4,000 ketamine infusions since the clinic’s inception, Wesana Clinics (the “Clinics”) have shown tremendous growth. The Clinics realized a record quarter in Q4 of billings, new patient visits, telemedicine utilization, overall patient appointments, and ketamine administrations. The record quarter can be attributed to an increase in marketing efforts inclusive of relationship building with the provider and therapist community and strategic and targeted marketing communications.

Wesana Clinics saw a 40% increase in new patient volume and a 29% increase in new appointments relative to the previous quarter. In December 2021, compared to the prior month, Ketamine infusions have also exceeded previous records by 52% while Spravato appointments have increased by 35%. Additionally, the Clinics are expanding access to mental health care through higher utilization of telemedicine appointments. Telemedicine appointments accounted for 57% of all appointments in the last quarter.

Dr. Abid Nazeer, Wesana’s Chief Medical Officer, commented: “I am incredibly pleased with the growth and optimization of the clinics since Wesana’s acquisition in September. Even taking into consideration the backdrop of increasing COVID-19 cases in Chicago, our ability to achieve record numbers is evidence that there is a growing need for accessible, effective, and patient-focused quality mental health care models that integrate established treatment approaches with novel care paradigms. Wesana’s expertise in marketing combined with our existing success in operations has created a winning combination for our patients and improved operating leverage for shareholders.”

Clinic Expansion within Chicago

The Company is also pleased to announce the expansion of clinical operations through the build-out of a third clinic in Naperville, Illinois. Strategically located approximately 25 minutes from the company’s clinic in Oak Brook, IL and 45 minutes from the clinic in downtown Chicago, the Naperville clinic will serve as a key expansion center that will benefit from existing referral sources and marketing initiatives as current locations reach capacity.

At approximately 3,100 square feet, the clinic will offer ketamine treatments in addition to existing Wesana Clinics insurance reimbursable services such as general psychiatric care, Spravato, individual psychotherapy, neurocognitive testing and addiction medicine. The Naperville clinic will also look to showcase the evolution of the clinics through new value-added, insurance reimbursable services such as deep Transcranial Magnetic Stimulation (“dTMS”), group psychotherapy, cognitive training and other mental health and wellness care. The launch of the clinic is currently targeted for late Q1 2022.

“The Naperville expansion is a natural evolution for our clinics business and allows us to realize our vision of Wesana Clinics 2.0,” commented Daniel Carcillo, Chief Executive Officer of Wesana Health. “Serving as our flagship, we are positioned to help the Naperville community with much needed mental health access through new integrated and more effective personalized approaches to healing. Based on our research and understanding of our patient population, we are confident that the new clinic will be a validation of our view on the evolution of our clinics business into a more comprehensive care model.”

Leadership Changes

Israel Mirsky, Chief Marketing and Strategy Officer of Wesana, has transitioned out of the organization to pursue other opportunities. As an early executive of Wesana, Mr. Mirsky was instrumental in building out the Company’s marketing function and in refining the Company’s strategy. The Company would like to thank Mr. Mirsky for his contributions in the early stages of the company and for his role in building out one of Wesana’s key functions.

Hayim Raclaw, Chief Operating Officer of Wesana, has transitioned out of the organization to pursue other opportunities. As co-founder and CEO of PsyTech, Hayim led the development of the clinics and clinical software divisions that now comprise the Care Delivery segment of Wesana. The Company would like to thank Mr. Raclaw for a successful integration of PsyTech’s assets into Wesana and for his contributions to the combined organization.

“On behalf of the management team, I would like to thank Israel and Hayim for their commitment and contributions to building Wesana to its current stage and wish them all the best in their future endeavors,” commented Daniel Carcillo. “As our strategy continues to evolve on both sides of our business, these transitions serve as needed steps to realize our vision of helping patients transcend the barriers in mental health and performance.”

Additional Restructuring

The Company also announces a strategic restructuring program as part of the next phase of the business. The restructuring includes a reorganization and simplification of the Company’s operating structure and a reduction in the workforce. The restructuring program specifically looked to reduce layers of management, remove duplicative roles, and outsource certain non-core functions in order to streamline operations and drive efficiency. The overall restructuring program has reduced general corporate overhead annualized commitments by $1.1M excluding charges associated with severance and related costs.

“We are announcing extensive changes today to make Wesana a stronger, more durable and focused company,” said Zed Wang, Chief Financial Officer of Wesana. “This includes making the difficult decision to part ways with some of our workforce. Saying goodbye to teammates is not a decision that was taken lightly, and we remain very grateful to everyone for their hard work and dedication to Wesana. These changes better positioned our organization by allowing our organization to be laser focused on executional excellence, R&D, quality and accessibility of care.”

On behalf of the Board of Directors:

“Daniel Carcillo” Chief Executive Officer

About Wesana Health

Wesana Health helps people transcend barriers in mental health and performance. We innovate in care development through our therapies and proprietary protocols, and in care delivery through activating a new multidisciplinary, technology-supported clinical model. Learn more at www.wesanahealth.com.

Investor Relations:

Keenan Gentry

Email: IR@wesanahealth.com 

Phone: 702.329.8038

Media Contacts:

Isadora Forman

Email: media@wesanahealth.com

Phone: 917.653.4613

Cautionary Note Regarding Forward-Looking Information

This press release contains “forward-looking information” within the meaning of applicable securities laws with respect to the Company, including, but not limited to: the initiation of Phase I clinical trials in late 2022, the launch of the Naperville clinic in late Q1 2022 and any other statement that may predict, forecast, indicate or imply future plans, intentions, levels of activity, results, financial position, operational or financial performance or achievements. Often, but not always, forward-looking information can be identified by the use of words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, “will”, “projects”, or “believes” or variations (including negative variations) of such words and phrases, or statements that certain actions, events, results or conditions “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. Except for statements of historical fact, information contained herein constitutes forward-looking information. Forward-looking information is not a guarantee of future performance and is based upon a number of estimates and assumptions of management at the date the statements are made.

Certain factors that influence successfully initiating Phase I clinical trials in late 2022 include: (i) the Company has retained industry leading experts/consultant to assist with strategy, drafting and submission of pre-IND/CTA meeting Packages; (ii) preparation of materials and internal discussions with consultants have been ongoing, productive and in line with timeline expectations; (iii) the Company has submitted an authorization letter to the FDA authorizing one of its Contact Research Organizations to communicate directly with the FDA on the Company’s behalf and personnel capable of attending the pre-IND/CTA meetings on behalf of the Company have been engaged; (iv) timelines for completion of pre-clinical studies and the receipt of a final report on the Anxiety and Depression Effects Study have been met; (v) the Company has identified the next key IND-enabling studies, including the pharmacology and toxicology assessments necessary to support submissions; (vi) the Company has substantially completed drafting the protocols for the above-referenced IND enabling studies, including the pharmacology and toxicology assessments; (vii) the pre-IND meeting is contemplated to provide the Company with the requisite guidance as to whether the protocols for the IND enabling studies are sufficient.

Certain assumptions that influence successfully initiating Phase I clinical trials in late 2022 include: (i) third parties assisting the Company with the pre-IND/CTA submissions will continue to satisfy deadlines on deliverables within anticipated timeframes; (ii) the pre-IND/CTA meetings are positive and support that a drug development plan and future clinical trials are going to be acceptable to the FDA and Health Canada; (iii) the Company and its consultants can efficiently and timely address any additional correspondence, submission of additional materials or information pursuant to any ongoing requests from FDA/Health Canada as they may arise during the course of their review following the filing of submissions; (iv) additional pre-clinical studies will be commenced and completed on a timely basis and results will be supportive and as anticipated; (v) the Company’s pre-clinical studies (animal pharmacology and toxicology testing) generate data and analyses to support an FDA decision that it is safe to proceed with human trials of the Company’s formulation; and (vi) the Company is able to maintain a GMP supply source necessary to conduct in-human clinical trials.

Certain factors that influence successfully launching the Naperville clinic in late Q1 2022 include: (i) the Company has identified a third clinic location and property and is finalizing the lease, (ii) should the Company procure additional capital and proceed with a lease in connection with the identified third property, renovations and permitting of the property for the purpose of clinic operations are expected to be minimal, and (iii) the Company has an internal team dedicated to identifying potential target clinics and locations and evaluating and addressing issues that may arise during due diligence of any potential targets.

Certain assumptions that influence successfully launching the Naperville clinic in late Q1 2022 include: (i) there are no significant delays in the buildout for the Naperville clinic early in Q1 2022, and (ii) there are no significant delays in renovation/permitting.

Furthermore, such forward-looking information involves known and unknown risks, uncertainties and other factors which may cause the actual performance, achievements, actions, events, results, or conditions of the Company to be materially different from any future performance, achievements, actions, events, results or conditions expressed or implied by such forward-looking information. Such factors include, among others: reliance on third parties to plan, conduct and monitor product research and development; failure to comply with health and data protection laws and regulations; violations of laws and regulations resulting in repercussions; regulatory or political change; maintaining and enhancing reputation and brand recognition; ability to protect intellectual property; requirements to share intellectual property with service providers; negative operating cash flow and going concern; the detrimental impact of future losses and negative cash flow from operations; unfavorable publicity or consumer perception; not achieving publicly announced milestones; psychedelic inspired drugs possibly never being approved as medicines; reliance on the capabilities and experience of key executives and scientists; disruptions due to acquisitions or collaborations; risk of product liability claims; COVID-19; litigation; conflicts of interest; limited operating history; exposure to the fluctuation of foreign exchange rates; enforcement of judgments and effecting service of process on directors and officers; general economic, market and business conditions, and other risks factors including those found in the Company’s annual information form dated September 3, 2021 filed on the Company’s profile on SEDAR at www.sedar.com and discussed in the Company’s other public filings available on SEDAR.

Although the Company has attempted to identify important factors that could cause actual results to differ materially, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such forward-looking information will prove to be accurate as actual results and future events could differ materially from those anticipated in such information. Accordingly, readers should not place undue reliance on forward-looking information. Forward-looking information is provided and made as of the date of this news release and the Company does not undertake any obligation to revise or update any forward-looking information other than as required by applicable law.

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Core One Labs Now Also Working to Biosynthesize DMT and Receives License

Core One Labs Now Also Working to Biosynthesize DMT and Receives License

Vancouver, British Columbia, Canada – January 8, 2022 – Core One Labs Inc. (CSE: COOL), (OTC: CLABF), (Frankfurt: LD6, WKN: A3CSSU) (“Core One” or the “Company”) is pleased to announce that it has progressed its work on biosynthesizing N,N-Dimethyltryptamine (“DMT”) and has been approved by Health Canada to add N,N-Dimethyltryptamine (“DMT”) to the schedule of approved controlled substances under the existing licence granted by the Controlled Drugs and Substances Act (”CDSA”) Dealer’s Licence (the “Licence”) which allows its wholly owned subsidiary Vocan Biotechnologies Inc. (“Vocan”) to research and produce biosynthetic psilocybin.

Furnished with its renewed licence in the second half of 2021, and having now received approval to add DMT to its licence coverage, the Company’s wholly-owned subsidiary Vocan Biotechnologies Inc. under its operating lab’s licence, has furthered its engineering and design optimization efforts for the proprietary manufacturing of API-grade DMT. The Company’s team of scientists at Vocan have been working diligently to expand a psychedelics production pipeline to include DMT. Initial indications of design and engineering suggest that using the same recombinant enzyme fermentation platform utilized to produce API-grade psilocybin, Vocan scientists will be able to replicate its biosynthesized psylocibin successes and announce ability to produce stereochemically sound biosynthesized DMT at scale.

The Company is confident that replication of historical research and development processes performed for its successful biosynthesis of psylocibin will allow for a more rapid turn around of its second biosynthesized psychedelic compound, DMT. Following similar processes of engineering and design may also increase probability of the Company’s filing of a patent for this second proprietary compound in the near term.

“Based on the significant progress we have made on biosythesizing psilocybin, DMT is the next compound we are working to biosynthesize. As we expect completion of the process for psilocybin in the upcoming days, we believe that we can fast track the process for DMT, as it uses the same steps to biosynthesize the compounds. Our team of leading scientists have done an amazing job in getting us to this stage and we are excited about the results we are seeing.” Stated Joel Shacker CEO of the Company.

ABOUT CORE ONE LABS INC.

Core One is a biotechnology research and technology life sciences enterprise focused on bringing psychedelic medicines to market through novel delivery systems and psychedelic assisted psychotherapy. Core One has developed a patent pending thin film oral strip (the “technology”) which dissolves instantly when placed in the mouth and delivers organic molecules in precise quantities to the bloodstream, maintaining excellent bioavailability. The Company intends to further develop and apply the technology to psychedelic compounds, such as psilocybin. Core One also holds an interest in medical clinics which maintain a combined database of over 275,000 patients. Through these clinics, the integration of its intellectual property, R&D related to psychedelic treatments and novel drug therapies, the Company intends to obtain regulatory research approval for the advancement of psychedelic-derived treatments for mental health disorders.

CORE ONE LABS INC.
Joel Shacker
Chief Executive Officer
FOR FURTHER INFORMATION:
Email: info@core1labs.com
Telephone: 1-866-347-5058

FOLLOW US:
Website: https://core1labs.com/
Twitter: https://twitter.com/Coreonelabs
Facebook: https://www.facebook.com/Core-One-Labs-Inc-100969251278277/
LinkedIn: https://www.linkedin.com/company/core-one-labs
Instagram: https://www.instagram.com/coreonelabsinc/

CAUTIONARY DISCLAIMER STATEMENT
The Canadian Securities Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of the content of this news release.
Information set forth in this news release contains forward-looking statements that are based on assumptions as of the date of this news release. These statements reflect management’s current estimates, beliefs, intentions, and expectations. They are not guarantees of future performance. The Company cautions that all forward-looking statements are inherently uncertain, and that actual performance may be affected by a number of material factors, many of which are beyond the Company’s control. Such factors include, among other things: risks and uncertainties relating to the Company’s limited operating history and the need to comply with strict regulatory regulations. Accordingly, actual and future events, conditions and results may differ materially from the estimates, beliefs, intentions and expectations expressed or implied in the forward-looking information. Except as required under applicable securities legislation, the Company undertakes no obligation to publicly update or revise forward-looking information.
In addition, psilocybin is currently a Schedule III drug under the Controlled Drugs and Substances Act (Canada) and it is a criminal offence to possess substances under the Controlled Drugs and Substances Act (Canada) without a prescription or authorization. Health Canada has not approved psilocybin as a drug for any indication. Core One does not have any direct or indirect involvement with illegal selling, production, or distribution of psychedelic substances in jurisdictions in which it operates. While Core One believes psychedelic substances can be used to treat certain medical conditions, it does not advocate for the legalization of psychedelics substances for recreational use. Core One does not deal with psychedelic substances, except within laboratory and clinical trial settings conducted within approved regulatory frameworks.

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Ketamine Wellness Centers To Open Salt Lake City Location

Ketamine Wellness Centers To Open Salt Lake City Location

Ketamine Wellness Centers (KWC) Announces Grand Opening of Salt Lake City Clinic

Salt Lake City location is the first in Utah and one of the largest ketamine clinics in the U.S., expands Delic’s network of clinics

VANCOUVER, BC, Jan. 6, 2022 /PRNewswire/ – Delic Holdings Corp (“Delic” or the “Company”) (CSE: DELC) (OTCQB: DELCF) (FRA: 6X0) (Original Source), a leader in new medicines and treatments for a modern world, today announced its subsidiary, Ketamine Wellness Centers (KWC), has officially expanded operations into Utah with the opening of its Salt Lake City location on January 10. KWC was acquired by Delic in September 2021 and currently operates 11 ketamine infusion treatment clinics across nine states, delivering more than 61,000 treatments to date.

Located in the suburb of Taylorsville at 6087 South Redwood Road, Suite B, KWC Salt Lake City is the first of the company’s clinics in Utah. With up to seven treatment rooms at the facility, this location will be one of the largest ketamine clinics in the U.S. and the largest ketamine infusion clinic in Utah. The clinic will also create 10 new jobs, with four filled at the outset and an additional six with a full patient schedule.

“Utah currently experiences one of the highest rates of mental health concerns in the country with lower access to care, and KWC aims to serve this new community of patients struggling with treatment-resistant conditions,” said Kevin Nicholson, CEO of KWC and Chief Operating Officer for Delic. “KWC is known for providing the highest standard of care and we are committed to providing the most effective and personalized treatment protocol to our patients and support and education to their loved ones.”  

The launch of KWC Salt Lake City allows Delic to execute its strategy of opening ketamine treatment centers in growing cities with the goal of reaching the greatest number of patients and providing reasonably priced treatments.

Matt Stang, co-founder and CEO of Delic, explained, “As the pandemic enters its third year, the need for effective, affordable options for mental health treatments is even more critical. We are thrilled to be opening the first KWC clinic in Utah and building on our promise to make these vital treatments more accessible by expanding our network into underserved communities where they are most needed.” 

To commemorate the grand opening, KWC Salt Lake City will host several events for the community to learn more about the clinic and ask questions about ketamine treatments, including an in-person and virtual meet and greet and a spring event that will bring together other local businesses. 

For more information about Ketamine Wellness Centers’ locations, services and hours of operation, please visit https://www.ketaminewellnesscenters.com/locations/. 

About Ketamine Wellness Centers

Ketamine Wellness Centers (KWC) is the largest ketamine therapy provider in the United States with 11 clinic locations serving communities across nine states. Since 2011 KWC has been a trusted leader in bringing IV ketamine therapy into mainstream health care. KWC has provided over 60,000 treatments to clinically eligible patients, from young adults to seniors, in addition to developing specialized programs for veterans and first responders. The KWC team, including a core group of physicians, psychologists, clinicians, and executives, is dedicated to providing value-based, personalized, clinically controlled ketamine infusion care for people suffering from treatment-resistant depression, anxiety, PTSD, OCD and chronic pain. KWC’s scalable business and treatment model is designed for further rapid expansion along with breakthrough innovations in effective therapies and services.

About Delic Corp

Delic is a leader in new medicines and treatments for a modern world, improving access to health benefits across the country and reframing the conversation on psychedelics. The company owns and operates an umbrella of related businesses, including the largest chain of psychedelic wellness clinics in the country, including Ketamine Infusion Centers and Ketamine Wellness Centers; the only licensed entity by Health Canada to exclusively focus on research and development of psilocybin vaporization technology, Delic Labs; the premier psychedelic wellness event, Meet Delic; and trusted media and e-commerce platforms Reality Sandwich and Delic Radio. Delic is backed by a team of industry and cannabis veterans and a diverse network, whose mission is to provide education, research, high-quality products, and effective treatment options to the masses.

The Canadian Securities Exchange has neither approved nor disapproved the contents of this news release and does not accept responsibility for the adequacy or accuracy of this release.

This news release does not constitute an offer to sell, or a solicitation of an offer to buy, any securities ‎in the United States. The securities have not been and will not be registered ‎under the United States ‎Securities Act of 1933, as amended (the “U.S. Securities Act”), or any state ‎securities laws and may not be offered or ‎sold within the United Statesunless registered under the U.S. ‎Securities Act and applicable state securities laws or an ‎exemption from such registration is available.‎

Forward-Looking Information and Statements

This press release contains certain “forward-looking information” within the meaning of applicable ‎Canadian securities ‎legislation and may also contain statements that may constitute “forward-looking ‎statements” within the meaning of ‎the safe harbor provisions of the United States Private Securities ‎Litigation Reform Act of 1995. Such forward-looking ‎information and forward-looking statements are not ‎representative of historical facts or information or current ‎condition, but instead represent only the ‎Company’s beliefs regarding future events, plans or objectives, many of ‎which, by their nature, are ‎inherently uncertain and outside of Delic’s control. Generally, such forward-looking ‎information or ‎forward-looking statements can be identified by the use of forward-looking terminology such as ‎‎”plans”, ‎‎”expects” or “does not expect”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, ‎‎‎”anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or may ‎contain ‎statements that certain actions, events or results “may”, “could”, “would”, “might” or “will be ‎taken”, “will continue”, ‎‎”will occur” or “will be achieved”. The forward-looking information and forward-‎looking statements contained herein ‎may include, but are not limited to: information regarding the timing or terms upon which the Transaction will be completed; potential benefits of the Transaction;  anticipated continued growth in the health and wellness sector (and, in particular, related to psychedelics); the ability of Delic to successfully achieve business ‎objectives, ‎and expectations ‎for other economic, ‎business, and/or competitive factors.‎

By identifying such information and statements in this manner, Delic is alerting the reader that ‎such ‎information and statements are subject to known and unknown risks, uncertainties and other factors ‎that may cause ‎the actual results, level of activity, performance or achievements of Delic to be ‎materially different from those ‎expressed or implied by such information and statements. Such risks and other factors may include, but are not limited to: risks and uncertainties relating to the Transaction not closing as planned or at all or on terms and conditions set forth in the Merger Agreement; incorrect assessment of the value and potential benefits of the Transaction; direct and indirect material adverse effects from the COVID-19 pandemic; inability to obtain future financing on suitable terms; failure to obtain required regulatory and other approvals; risks inherent in the psychedelic treatment sector; changes in applicable laws and regulations; and failure to comply with applicable laws and regulations.

In addition, in connection with the forward-looking ‎information and forward-looking statements contained in this press ‎release, Delic has made certain ‎assumptions. These assumptions include, but are not limited to: assumptions as to the time required to negotiate a definite agreement and complete matters related to the Transaction; the ability to consummate the Transaction; ‎the ability of the parties to ‎obtain, in a timely manner, the requisite regulatory, corporate and other third party approvals and the satisfaction of ‎other conditions to the ‎consummation of the Transaction on the proposed terms; the potential impact of the announcement or consummation of the Transaction on ‎relationships, ‎including with regulatory bodies, employees, suppliers, customers and competitors; ‎changes in general economic, ‎business and political conditions, including changes in the financial ‎markets; changes in applicable laws; compliance ‎with extensive government regulation; and the diversion ‎of management time on the Transaction.‎

Should one or more of these risks, uncertainties or other factors materialize, or should assumptions ‎underlying the ‎forward-looking information or statements prove incorrect, actual results may vary ‎materially from those described ‎herein as intended, planned, anticipated, believed, estimated or ‎expected.‎

rich@deliccorp.com

Although Delic believes that the assumptions and factors used in preparing, and the expectations ‎contained ‎in, the forward-looking information and statements are reasonable, undue reliance should not ‎be placed on such ‎information and statements, and no assurance or guarantee can be given that such ‎forward-looking information and ‎statements will prove to be accurate, as actual results and future events ‎could differ materially from those anticipated ‎in such information and statements. The forward-looking ‎information and forward-looking statements contained in this ‎press release are made as of the date of ‎this press release, and Delic does not undertake to update any ‎forward-looking information ‎and/or forward-looking statements that are contained or referenced herein, except in ‎accordance with ‎applicable securities laws. All subsequent written and oral forward- looking information and ‎statements ‎attributable to Delic or persons acting on its behalf is expressly qualified in its entirety by this ‎‎notice.‎

Investor Relations Contact
Rich Rodriguez
rich@deliccorp.com

Media Contact
Noah Bethke
MATTIO Communications
delic@mattio.com

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Doseology Completes Development and Test Marketing of Adaptogenic Mushroom Product Line

Doseology Completes Development and Test Marketing of Adaptogenic Mushroom Product Line

Vernon, British Columbia, January 6, 2022 – Doseology Sciences Inc. (CSE: MOOD) (“Doseology” or the “Company”), a British Columbia-based diversified life sciences company developing mushroom-based health and wellness solutions, announces the successful soft launch of seven new adaptogenic mushroom products in the United States, and the upcoming launch of the product line in the Canadian market during the first quarter of 2022.

Doseology’s new medicinal mushroom products have successfully completed test marketing with overwhelmingly positive ratings and reviews. Being among the most comprehensive available on the market, they will help fill the growing demand for high-quality adaptogenic nutraceuticals. The new line employs adaptogenic blends to improve on the single-extract tinctures commonly available. Blends have a higher market value because of increased user benefits and development challenges. 

The proprietary formulations make extensive use of natural mushroom fruiting bodies, pairing adaptogenic botanicals with vitamins for increased efficacy.  Significant research has shown positive effects of adaptogens with respect to stress reduction, resistance to mental fatigue, and improved attention capacity. The Doseology line combines adaptogens such as ginger, turmeric, yerba mate, and several mushroom species, with proven functional mushrooms such as lion’s mane, reishi, shiitake, maitake, royal sun, turkey tail, and others. These blended formulations deliver enhanced health and wellness benefits over single-ingredient products.

The new product line addresses the functional mushroom market, projected to grow to US$572 billion globally by 2028 with a CAGR of 6.1 percent (Data Bridge Market Research). Products in the new Doseology line address different segments of the market, including mood and depression, attention and focus, sleep and recovery, and anxiety.

In preparation for the Canadian launch, Doseology has received six Natural Product Number (NPN) licenses from Health Canada. The Company is currently exploring Canadian distribution channels, which is planned to include Amazon.ca. With US$7.14 billion in net sales (Statista, 2020), Amazon.ca is by a wide margin Canada’s largest online retailer. The Company’s direct marketing focus will enable it to quickly reach consumers who can benefit most, provide an engaging customer experience, and establish long-term relationships to maximize revenue. 

Daniel Vice, Doseology CEO and Director, comments, “After many months of product development, testing, and regulatory approval, we are pleased to finally launch our products in the U.S. market, and soon in Canada. By incorporating the nutrient-dense fruiting bodies of functional mushrooms and natural health-promoting adaptogens, our products were designed to optimize the user experience which reflects our commitment to deliver high-quality, natural solutions to improve physical & mental health.”

A core element of the Company’s mission is developing and providing psychedelic treatments for restoring mental health. Once the regulatory framework has been established, Doseology’s product line will form the foundation for psilocybin-based therapeutics, creating an entirely new market and fulfilling the Company’s vision of better mental health and wellness for millions globally.

Doseology has completed its application with Health Canada to become a “Licensed Dealer” under the Controlled Drugs and Substances Act (Canada), which would permit the production of psychedelic compounds including psilocybin and psilocin, and mark a significant milestone in achieving the Company’s vision.

These announced developments will give consumers better access to the healing power of medicinal mushrooms, and bring Doseology closer to delivering innovative wellness solutions and mental health therapies.

Learn more about Doseology’s medicinal mushroom product line at doseology.com.

On Behalf of the Board of Directors

Daniel Vice
Chief Executive Officer and Director
Doseology Sciences Inc.

About Doseology Sciences Inc.
Doseology Sciences Inc. (CSE: MOOD) is a British Columbia-based diversified life sciences company, on a mission to reimagine mental health therapies through innovation, technology and sustainability. With a focus on psychedelic and non-psychedelic compounds, Doseology will offer cutting-edge therapeutic products and services, with the aim of making a meaningful impact on the mental health pandemic and improving overall health.

For further information contact:
Investor Relations: investor@doseology.com
Media Inquiries: media@doseology.com
Telephone: 236-349-0064
Website: www.doseology.com

Forward Looking Statements
This corporate update contains statements which constitute “forward‐looking information” within the meaning of applicable securities laws. Forward‐looking information is often identified by the words “may,” “would,” “could,” “should,” “will,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “expect” or similar expressions. Readers are cautioned that forward‐looking information is not based on historical facts but instead reflects the Company’s management’s expectations, estimates or projections concerning the business of the Company’s future results or events based on the opinions, assumptions and estimates of management considered reasonable at the date the statements are made. Although the Company believes that the expectations reflected in such forward‐looking information are reasonable, such information involves risks and uncertainties, and undue reliance should not be placed on such information, as unknown or unpredictable factors could have material adverse effects on future results, performance or achievements. Among the key factors that could cause actual results to differ materially from those projected in the forward‐looking information are the following: changes in general economic, business and political conditions, including changes in the financial markets; decreases in the prevailing prices for products in the markets that the Company operates in; adverse changes in applicable laws or adverse changes in the application or enforcement of current laws; regulations and enforcement priorities of governmental authorities; compliance with government regulation and related costs; and other risks described in the Prospectus. Should one or more of these risks or uncertainties materialize, or should assumptions underlying the forward‐looking information prove incorrect, actual results may vary materially from those described herein as intended, planned, anticipated, believed, estimated, or expected. Although the Company has attempted to identify important risks, uncertainties and factors which could cause actual results to differ materially, there may be others that cause results not to be as anticipated, estimated or intended. The Company does not intend, and does not assume any obligation, to update this forward‐looking information except as otherwise required by applicable law.

No securities regulatory authority has either approved or disapproved of the contents of this news release. The Company’s securities have not been, nor will they be, registered under the United States Securities Act of 1933, as amended, or any state securities laws, and may not be offered or sold in the United States, or to or for the account or benefit of any person in the United States, absent registration or an applicable exemption from the registration requirements. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any securities in the United States, or in any other jurisdiction in which such offer, solicitation or sale would be unlawful.

The CSE does not accept responsibility for the adequacy or accuracy of this release.

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Ketamine One Appoints Two New Members to Its Medical Advisory Board

Ketamine One Appoints Two New Members to Its Medical Advisory Board

Corey Hilmas, MD, PhD and Brigadier General (Ret.) Loree K. Sutton, MD Will Help Guide the Development of the Company’s Mental Health Platform 

Vancouver, British Columbia, January 5, 2022 / Globe Newswire / – KetamineOne Capital Limited  (“Ketamine One” or the “Company”) (NEO: MEDI) (OTC: KONEF) (Frankfurt: MY0), a company  focused on consolidating medical clinics and becoming a North American leader in mental health  treatments, is pleased to announce that Corey Hilmas, MD, PhD has been appointed to the Company’s  Medical Advisory Board (“MAB”) and will be assuming the role of Interim Chair of the MAB.  Additionally, Brigadier General (Ret.) Loree K. Sutton, MD, has also been appointed to the MAB.  

Dr. Hilmas currently also serves as the Chief Regulatory Officer of the Company’s wholly owned  subsidiary, KGK Science Inc. He is a respected scientist, medical doctor, and former federal food regulator  in the United States (“US”). After having completed his medical degree and doctorate in toxicology,  working as a principal investigator for many years, and serving on behalf of the US government at the Food  and Drug Administration (“FDA”), Dr. Hilmas combines his unique medical and scientific skillset with  extensive U.S. regulatory training. He served as an New Dietary Ingredients notification reviewer and as a  branch chief within the Division of Dietary Supplement Programs at the FDA.  

In addition to working on enforcement matters related to supplement labeling, claims, good manufacturing  practices and fraud, he also served as an expert witness for the FDA and Department of Justice, resulting  in an FDA Award of Merit from former FDA Commissioner Margaret Hamburg. As a recognized  regulatory expert with intimate knowledge of the dietary supplement industry, Dr. Hilmas has made  significant contributions to building and shaping the regulatory landscape through drafting over 65  comments to multiple US federal and state agencies as well as global food health directorates on topics  ranging from soy to supplements and cannabidiol, to changing regulatory frameworks overseas.  

Dr. Sutton is a lifelong public servant, physician and retired brigadier general who was the Army’s highest ranking psychiatrist. She is the co-founder of Threshold GlobalWorks, LLC; the founding commissioner of  the NYC Department of Veterans’ Services; and, in her current position as CEO, Veteran Services USA,  has devoted over 35 years of service and leadership to the nation and New York. Sutton’s decorated military  career includes earning a Bronze Star for her actions in combat while deployed to Operation Desert Storm.  Selected as a White House Fellow, the nation’s premier leadership program, and honored by the National  War College as a distinguished graduate, she also commanded the Carl R. Darnall Army Medical Center at  Fort Hood, TX during the height of Operation Iraqi Freedom hostilities. 

Serving as the founding director, Defense Centers of Excellence for Psychological Health and Traumatic  Brain Injury, Loree pioneered integrative approaches for building resilience, enhancing recovery and  fostering community reintegration. Spanning decades of service in the public and private sectors, her  visionary leadership has yielded transformational change which continues to improve the lives of veterans,  families, caregivers and survivors.  

Additionally, Ketamine One has granted certain advisors an aggregate amount of 100,000 stock options to purchase up to 100,000 common shares of the Company, at a price of $0.30 per common share for a period of five years from the date of grant, pursuant to its stock option plan that was approved by shareholders on Feb. 21, 2021. Fifty per cent of the options vest six months from the date of grant, with the remaining fifty per cent of the options vesting 12 months after the date of the grant.  

ABOUT KETAMINE ONE 

KetamineOne Capital Limited (formerly Myconic Capital Corp.) is a company focused on consolidating  medical clinics and becoming a North American leader in mental health treatments. It is working to provide  the critical infrastructure needed to develop and deliver breakthrough mental health treatments. Currently,  Ketamine One has a network of clinics across North America, with plans to further consolidate the highly  fragmented industry. KGK Science Inc. is the Company’s wholly owned contract research division, which  places it at the forefront of premium clinical research based on the subsidiary’s history and extensive  experience in pharmaceuticals, cannabis, and the emerging psychedelic medicine industries. As a collective  enterprise, Ketamine One is dedicated to helping solve the growing need for safe and accessible mental  health therapy.  

On behalf of:  

KETAMINE ONE 

“Adam Deffett”  

Adam Deffett, Interim CEO  

For further information, please contact:  

Nick Kuzyk, Investor Relations  

Tel: 1-844-PHONE-K1 (1-844-746-6351)  

Email: IR@ketamine.one  

Web: www.ketamine.one 

Twitter: @KetamineOne  

Notice Regarding Forward-Looking Information: 

This news release contains forward-looking statements including but not limited to statements regarding the Company’s business, assets or investments, as well other statements that are not historical facts. Readers are cautioned not to place undue reliance on forward-looking statements, as there can be no assurance that the plans, intentions or expectations upon which they are based will occur. By their nature, forward-looking statements involve numerous assumptions, known and unknown risks and uncertainties, both general and specific, that contribute to the possibility that the predictions, forecasts, projections and other forward 

looking statements will not occur, which may cause actual performance and results in future periods to differ materially from any estimates or projections of future performance or results expressed or implied by 

such forward-looking statements. These assumptions, risks and uncertainties include, among other things, the state of the economy in general and capital markets in particular, investor interest in the business and prospects of the Company.  

The forward-looking statements contained in this news release are made as of the date of this news release. Except as required by law, the Company disclaims any intention and assumes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable securities law. Additionally, the Company undertakes no obligation to comment on the expectations of, or statements made, by third parties in respect of the matters discussed above.  

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Core One Labs Applauds Health Canada’s Amendments to Special Access Program, Allowing Physicians to Request Patient Access to Psychedelic Treatments

Core One Labs Applauds Health Canada’s Amendments to Special Access Program, Allowing Physicians to Request Patient Access to Psychedelic Treatments

Vancouver, British Columbia, Canada – January 5, 2022 – Core One Labs Inc. (CSE: COOL), (OTC: CLABF), (Frankfurt: LD6, WKN: A3CSSU) (the “Company” or “Core One”) applauds Health Canada for its recent amendment to the Special Access Programme (SAP), which will now allow physicians to request patient access to psychedelic treatments, including psilocybin-assisted therapy.

The amendments under the SAP came into effect as of today, January 5, 2022, as published in the Canada Gazette, and allows physicians to request psychedelic treatments on behalf of their patients, on a case-by-case basis, for serious treatment-resistant or life-threatening conditions. This significant amendment has the potential to provide numerous Canadians struggling with serious mental health afflictions with alternative therapies where traditional treatments have failed, or where other treatments are unsuitable or are unavailable in Canada.

Canada’s SAP was designed with the purpose of allowing people access to new, potentially life-saving medications before they are formally approved for routine use in healthcare, however prior to today’s milestone amendment, psychedelic medications have been ineligible for Special Access Programme applications. Today’s regulatory amendment will enable Canadian physicians to apply for psychedelic therapies in a similar process as to how other investigational medications are accessed prior to formal drug approval.

The amendment to SAP by Health Canada is an historic milestone in Canada’s approach to treating mental health conditions and signifies a growing recognition of the important and growing body of research that supports the efficacy of psychedelics and psychedelic-assisted therapies in treating mental health afflictions. According to Health Canada, access to psychedelic treatments will be provided where there is sufficient data to support the safety and efficacy of the targeted drug for a patient’s specific condition.

Under the SAP patients are not eligible to make direct application for access to psychedelic therapies, only licensed healthcare practitioners who are authorized under the laws of a province or territory to treat patients with a prescription drug may file requests through the SAP.

“This is an incredibly important milestone for Canada,” stated Joel Shacker, Core One CEO. “Health Canada’s amendment to the Special Access Program, has the potential to improve the lives or numerous Canadians suffering from mental health afflictions, including major depression, end-of-life anxiety and even addictions and historical traumas. It also provides doctors and their patients a safe, legal and regulated process for providing alternative treatments to mental health patients that desperately seek alternatives to otherwise failing contemporary modalities. Core One applauds Health Canada’s serious approach to mental health reform, and feels a brighter future is in near sight for many Canadians. Well done, Canada!”

In addition to applauding the historic amendments made by Health Canada to the SAP, the Company also announces that, further to its press release dated December 22, 2021, the Company has removed the voluntary pooling restrictions on the 5,814,000 common shares issued in connection with its acquisition of New Path Laboratories Inc., which includes 114,000 common shares issued to certain third parties who provided administrative services necessary to complete the Transaction.

The Company further announces that is has granted a total of 2,144,000 Restricted Share Units (the “RSUs”) to certain eligible consultants, directors, officers, and employees under its 10% rolling Restricted Share Unit Plan. The RSUs will vest in four (4) months. All the RSUs (and any common shares issuable upon redemption) will be subject to applicable securities law hold periods.

About Core One Labs Inc.
Core One Labs Inc. is a research and technology company focused in life sciences and on bringing psychedelic medicines to market through novel delivery systems and psychedelic assisted psychotherapy. The Company has developed a patent pending thin film oral strip (the “technology”) which dissolves instantly when placed in the mouth and delivers organic molecules in precise quantities to the bloodstream, maintaining excellent bioavailability. With this technology, the Company intends to further develop its IP technology to focus on delivering psychedelic molecules with an initial focus on psilocybin. Core One also holds an interest in walk-in medical clinics which maintain a database of over 200,000 patients combined. Through research and development in these clinics, including the integration of its intellectual property related to psychedelic treatments and novel drug therapies, the Company intends to work towards regulatory approval for research that advances psychedelic-derived treatments for mental health disorders.

Core One Labs Inc.
Joel Shacker
Chief Executive Officer

FOR MORE INFORMATION, PLEASE CONTACT:
info@core1labs.com
1-866-347-5058

Cautionary Disclaimer Statement:

The Canadian Securities Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of the content of this news release.

Information set forth in this news release contains forward-looking statements that are based on assumptions as of the date of this news release. These statements reflect management’s current estimates, beliefs, intentions, and expectations. They are not guarantees of future performance. The Company cautions that all forward-looking statements are inherently uncertain, and that actual performance may be affected by a number of material factors, many of which are beyond the Company’s control. Such factors include, among other things: risks and uncertainties relating to the Company’s limited operating history and the need to comply with strict regulatory regulations. Accordingly, actual and future events, conditions and results may differ materially from the estimates, beliefs, intentions and expectations expressed or implied in the forward-looking information. Except as required under applicable securities legislation, the Company undertakes no obligation to publicly update or revise forward-looking information.

In addition, psilocybin is currently a Schedule III drug under the Controlled Drugs and Substances Act (Canada) and it is a criminal offence to possess substances under the Controlled Drugs and Substances Act (Canada) without a prescription or authorization. Health Canada has not approved psilocybin as a drug for any indication. Core One does not have any direct or indirect involvement with illegal selling, production, or distribution of psychedelic substances in jurisdictions in which it operates. While Core One believes psychedelic substances can be used to treat certain medical conditions, it does not advocate for the legalization of psychedelics substances for recreational use. Core One does not deal with psychedelic substances, except within laboratory and clinical trial settings conducted within approved regulatory frameworks.

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M2Bio Rolls Out Sustainable Packaging for Liviana

M2Bio Rolls Out Sustainable Packaging for Liviana

CAPE TOWN, SOUTH AFRICA / ACCESSWIRE / December 31, 2021 /WUHAN GENERAL GROUP, INC. (WUHN) (“WGG” or the “Company”), a bioceutical company focused on alternative plant-based cannabinoids and mental health therapeutic research is pleased to share the following update:

M2Bio Sciences is pleased to announce the rollout of its sustainable packaging solution – Hempcelium™ to be piloted and implemented by it’s Liviana™ Extra Virgin Olive Oil brand. The state-of-the-art sustainable packaging is customized to fit its Extra Virgin Olive Oil glass bottles. The solution is a Hempcelium™ transport packaging foam made from hemp agri-waste and mushroom mycelium.

Hempcelium™ is a unique composite that outperforms most other sustainable alternatives currently available. The Hempcelium™ packaging structure is completely organic and can be grown into almost any shape, making it as versatile as styrofoam or polystyrene, less the damage and pollution that comes from using a conventional synthetic material. Because Hempcelium™ is grown and not produced with chemical compounds that need large amounts of energy to synthesize, the carbon footprint is very low, and there are zero industrial chemical byproducts emitted that are harmful to the natural environment, our water, ecosystems, food-chains and human health.

The unique Hempcelium™ composite has been developed in-house by its team of engineers at the M2Bio Sustainability Labs during 2021 and is ready for the South African market. The company is in the process of obtaining all necessary legal and copyrights pertaining to the trademark name Hempcelium™. M2Bio Sciences’ Intellectual Property and Trademark legal team expects the process to be successfully concluded in Q1 2022.

“When you get the product with the packaging you are able to crumble up the Hempcelium™ foam into your garden bed or soil to decompose and support the health of your vegetation. Hempcelium serves an important function in the decomposition of organic matter in the soil. Research has demonstrated that it acts as a filter, removing groundwater contaminants and pollutants. It has shown potential to remove industrial toxins from the soil, which includes pesticides, chlorine, dioxin (a highly toxic environmental pollutant) as well as PCBs (highly toxic industrial compounds). In the garden, Hempcelium helps to increase nutrients available to plants, improve water efficiency, reduce erosion by acting as a cellular net, and promote root growth by adding oxygen to the soil and releasing nitrogen, phosphate, and other micronutrients. Simply put, it has a ton of benefits.” – Jeff Robinson, CEO of M2Bio Sciences.

Hempcelium™ packaging solution for single & multiple bottles

Mr. Robinson continues: “We and our customers are increasingly aware of the importance of sustainable and biodegradable materials. As a company, it has been at the core of product development to ensure all of our materials and ingredients adhere to such standards. We are now proud to take it to the next level, and deliver our own innovative solution to our customers, by introducing our sustainable packaging foam to one of our brands, Liviana.”

In addition, M2Bio is developing multiple packaging solutions for its other product lines and brands – Medspresso™ and Dr. AnnaRx™, which will be ready during the course of 2022.

“This will be a watershed moment for the sustainability drive globally. M2Bio will licence the technology to the rest of the world, with the goal of reducing and replacing synthetics entirely. We are super stoked for what comes next” – Jeff Robinson, CEO of M2Bio Sciences.

Hempcelium™ packaging solution for Dr. AnnaRx products

About Wuhan General Group, Inc./ M2Bio Sciences, Inc

Wuhan General Group, Inc. (DBA M2bio Sciences), through its wholly-owned subsidiary MJ MedTech is a nutraceutical biotechnology company focused on alternative plant-based cannabinoids and psilocybin medical research that develops and commercializes a range of CBD and mushrooms-based products under Dr. AnnaRx™, Medspresso™, and Liviana™ brands. In addition, our research and clinical trials with psilocybin are aimed at new therapies that will help patients who suffer from alcohol addiction, mental illness, and cardiovascular diseases. Our mission is to advance botanical-based medicine to the forefront by deploying best-practice science and medicine, clinical research, and emerging technologies. The Company is traded on the Over-the-Counter Bulletin Board of NASDAQ under the trading symbol “WUHN”.

Publicly traded company (OTC Pink: WUHN)

Website: www.m2bio.co

E-mail: info@m2bio.co

Follow us on Twitter: https://twitter.com/m2bio

Follow us on Facebook: http://www.facebook.com/m2bio

Follow us on YouTube: https://www.youtube.com/channel/M2BioSciences

Follow us on Instagram: https://www.instagram.com/m2bio.sciences/

Forward-Looking Statements:

Safe Harbour Statement – In addition to historical information, this press release may contain statements that constitute forward-looking statements within the meaning of the Securities Act of 1933 and the Securities Exchange Act of 1934, as amended by the Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this press release include the intent, belief, or expectations of the Company and members of its management team with respect to the Company’s future business operations and the assumptions upon which such statements are based. Prospective investors are cautioned that any such forward-looking statements are not guarantees of future performance, and involve risks and uncertainties and that actual results may differ materially from those contemplated by such forward-looking statements. Factors that could cause these differences include, but are not limited to, failure to complete anticipated sales under negotiations, lack of revenue growth, client discontinuances, failure to realize improvements in performance, efficiency and profitability, and adverse developments with respect to litigation or increased litigation costs, the operation or performance of the Company’s business units or the market price of its common stock. Additional factors that could cause actual results to differ materially from those contemplated within this press release can also be found on the Company’s website. The Company disclaims any responsibility to update any forward-looking statements.

SOURCE: Wuhan General Group, Inc./ M2Bio Sciences, Inc.

View source version on accesswire.com:
https://www.accesswire.com/680355/M2Bio-Rolls-Out-Sustainable-Packaging-for-Liviana

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2021 Psychedelics Unwrapped // 2022 Year of the 🍄: issue 30

Hello and welcome back for the final issue of the year.

2021 proved to be a monumental year for the psychedelic sector. We saw more psychedelic research than ever before, and the medicines became widely accepted by the public and mainstream media (we like to think that we helped with that 😉).

In this special issue, we’ll review this year’s top advancements, scientific breakthroughs, and legislation changes that have moved the psychedelic revolution forward.

Whether you’ve been following along since Issue 1 or you’re brand new to the Daily Mushroom Community – thank you for joining us 🧡 We are so grateful that we can use this platform to give psychedelic medicine the attention it deserves. 

We’ll see you in the New Year with an exciting announcement!

Don’t miss a Daily Mushroom Podcast!

 In 2021, we heard stories from:

  • The first Canadian to receive legal psilocybin therapy
  • CEOs of major psychedelic companies
  • The founder of a ketamine-assisted group therapy workshop
  • A veteran who cured his pain and PTSD with a (wild) DMT trip
  • And many more amazing guests

Listen now on YouTube, Spotify, or Apple ⬇️

Therapeutic banner

MDMA was found to be an extremely promising PTSD treatment

The Multidisciplinary Association for Psychedelic Studies (MAPS) conducted the first-ever Phase 3 trial for psychedelic-assisted therapy – and the results were incredible.

Patients with chronic PTSD (many battling the condition for over 20 years) finally found relief after three sessions of MDMA-assisted therapy.

Of the 46 patients, two-thirds no longer qualified for a PTSD diagnosis and 88% experienced a clinically significant reduction in symptoms after the sessions 👏

Researchers explain that MDMA reduces activity in the amygdala, a part of the brain associated with fear response, allowing patients to process trauma in therapy without becoming overwhelmed.

MAPS expects that MDMA therapy will become FDA-approved in 2023. The non-profit has begun patient enrollment for a second study of similar nature, so stay tuned for the results.

Psilocybin out-performed a leading antidepressant…

A study conducted by Dr. Robin Carhart-Harris at Imperial College London suggests that psilocybin is more effective than antidepressants – and with fewer side effects.

Patients with mild-to-severe depression were given either a daily dose of escitalopram (aka Lexapro) or two doses of psilocybin. 

In the psilocybin group:

  • 70% saw at least a 50% reduction in depression scores, with an average decrease of 8.0 points
  • 57% were in remission at week 6, meaning they no longer qualified for a depression diagnosis
  • Patients were more likely to report improvements in the ability to feel compassion, pleasure, and intense emotion
  • No patient requested to stop dosing
  • The most common adverse event was headache

In the escitalopram group:

  • 48% saw at least a 50% reduction in depression scores, with an average decrease of 6.0 points
  • 28% were in remission from depression at week 6
  • Patients were more likely to experience anxiety, dry mouth, sexual dysfunction, drowsiness, and reduced emotional responsiveness
  • 4 patients stopped dosing and 1 halved their dose due to adverse side effects 

…and became widely accepted as viable treatment

These magazine covers say it all – just look how far we’ve come!

Research revealed that psychedelics help the brain grow

Yale researchers discovered that psilocybin regrows and strengthens neuronal connections that can be lost due to depression or chronic stress.

Two months later, Algernon Pharmaceuticals (AGN) found that DMT was even more effective at growing neuronal connections, even at sub-hallucinogenic doses 🤯

The formation of new connections could explain why psychedelics are so effective at altering negative thought patterns and fostering positive behaviour change!

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Psychedelic research received gov’t funding for first time in 50 years

When the War on Drugs was declared in the 70s, the US federal government stopped funding psychedelic research. 

Things changed this September, when Johns Hopkins researcher Dr. Matthew W. Johnson received a grant from the National Institute on Drug Abuse (NIDA) to conduct a psilocybin study on tobacco addiction.

So far, his research has suggested that psilocybin is more than twice as effective at treating addiction than nicotine patches.  

The Canadian government also began funding psilocybin research, with a grant given to MYND Life Sciences (MYND) to study depression and neuroinflammation.

Canada expanded access to psilocybin therapy 🇨🇦

Earlier this month, three Canadians gained legal exemptions to access psilocybin therapy to treat mental health conditions. This marked an exciting turning point by expanding access to the treatment beyond end-of-life care.

DMT was fast-tracked in the UK 🇬🇧

In October, Small Pharma’s DMT program for depression was found to be so promising that it was granted an Innovation Passport Designation from the UK Medicines and Healthcare products Regulatory Agency (MHRA).

The designation will give Small Pharma access to specialist advice to expedite the drug development process and facilitate patient access to the treatment.

Once approved, DMT could make psychedelic therapy more accessible and affordable because the trip takes just 20 minutes, yet produces long lasting effects!

Microdosing took the world by storm 💊

We saw an explosion of microdosing research this year, including the largest psychedelic study to date, which revealed that microdosers exhibit lower levels of depression, anxiety, and stress than non-microdosers. Many other intriguing studies have been initiated such as:

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Companies around the world jumped on the psychedelic bandwagon

With more and more research confirming the incredible healing power of psychedelics, it’s no surprise that we’ve seen a tremendous amount of capital invested in the sector this year. 

At the beginning of the year, there were just a handful of publicly-traded psychedelic companies.  Now, there are over 70 public companies working to bring psychedelic medicines to market – some valued at over $1 billion! 🚀

The first-ever psychedelic indexes were launched

In 2021, it became easier than ever to diversify your psychedelic portfolio 🤑

In January, Horizons ETFs Management debuted PSYK on Toronto’s NEO exchange, becoming the first exchange traded fund for psychedelic stocks.

Later in the year, two more ETFs were introduced on US exchanges – Definace ETFs’ PSY, a passive fund, and AdvisorShares’ PSIL, an actively managed fund.

Private investments reached record highs

Private investments in psychedelic companies reached $595M across 45 deals this November —  that’s an increase of 66% from last year and 625% higher than in 2019 📈

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We saw widespread drug reform across both red and blue states…

Some or all psychedelics were decriminalized in:

More big wins:

  • Texas and Connecticut passed bills to study the therapeutic potential of psilocybin.
  • New Jersey successfully reduced the criminal penalties for possession of psilocybin.
  • The DEA increased production quotas for psilocybin, psilocin, MDMA, and DMT for both 2021 and 2022, allowing more research to be conducted.

We saw widespread drug reform across both red and blue states…

Legislation was filed to decriminalize psychedelics in:

Legislation was filed to promote psychedelic research or legalize therapeutic use in:

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Core One Labs Acquires New Path Laboratories

Core One Labs Acquires New Path Laboratories

Vancouver, British Columbia, Canada – December 23, 2021 – Core One Labs Inc. (CSE: COOL), (OTC: CLABF), (Frankfurt: LD6, WKN: A3CSSU) (the “Company” or “Core One”) is a research and development company focused on bringing psychedelic medicines to market through the development and production of API grade psychedelic compounds, the advancement of psychedelic assisted treatments, and the integration of novel delivery system technology. The Company is pleased to announce it has completed the acquisition (the “Transaction”) of all of the outstanding share capital of New Path Laboratories Inc. (“New Path”).

Based in British Columbia, New Path is dedicated to the development and licencing of natural health products and dietary supplements incorporating functional mushrooms to help support every day biological functions in the maintenance of good health. New Path’s vertical integration model will allow it to grow, develop, and distribute its natural health products and dietary supplements from spore to sale. New Path’s equipment and infrastructure along with its proprietary mycelium process allow for the low-cost production of its products.

New Path currently has two retail components, Nue Mindset and Forest Garden Mushrooms, both of which specialize in functional, non-psychedelic, mushroom products. Nue Mindset, which is currently awaiting Health Canada’s Natural Health Product Number approval, produces a Lion’s Mane mushroom powder infused with Vitamin B3, to assist in improving cognitive function. The Lion’s Mane mix has received pre-orders from both local and online retail outlets. Concurrently, Forest Garden produces an immune boosting capsule line made from Chaga, Cordyceps, Reishi, Maitake and Lion’s Mane mushrooms. New Path also manufactures a simple to use and easy to distribute Lion’s Mane mushroom grow kit. Forest Garden plans to sell its products through Nue Mindset’s already established retail channels.

Medicinal mushrooms are ranked as a Top 10 Food Trend by Whole Foods. They have been used as a health aid, mainly in eastern medicine, for over 2000 years. At present, functional mushrooms such as Chaga, Lion’s Mane, Reishi, Maitake, Cordyceps and Turkey Tail are quickly becoming the latest superfood trend. Mushrooms act as antibacterial immune system enhancers and help to improve brain health and increase cognitive abilities. Functional mushrooms contain important bioactive compounds and can even help to lower cholesterol. Importantly, animal studies have also suggested that compounds in the functional mushroom Chaga have shown to selectively kill cancer cells and help stimulate the immune system. These benefits along with proactive health care and plant-based lifestyle changes suggest that it can be expected that North America will witness significant growth in the functional mushroom market.

Joel Shacker, CEO of the Company stated, “This acquisition further extends the Company’s presence in the functional mushrooms space and also will allow the Company to generate sales revenue by virtue of adding retail distribution channels to its business model and reach an exponentially growing consumer base.”

Transaction Structure

The Transaction was completed pursuant to a share purchase agreement among the Company, New Path and the shareholders of New Path (the “Definitive Agreement”) dated effective December 22, 2021. Pursuant to the Definitive Agreement, and in consideration for the acquisition of New Path, the Company has issued 5,700,000 common shares (the “Consideration Shares”). The Consideration Shares are subject to a voluntary pooling arrangement during which time the holders are restricted from trading the shares. The Consideration Shares will be released from the arrangement in four equal tranches over a period of nine-months with the first tranche being released upon closing of the Transaction and each subsequent tranche every three months thereafter.

The Company is at arms-length from New Path and its shareholders. The Transaction neither constitutes a fundamental change nor a change of business for the Company, nor has it resulted in a change of control of the Company within the meaning applicable securities laws and the policies of the Canadian Securities Exchange. In connection with completion of the Transaction, the Company has issued 114,500 common shares to certain third-parties who provided administrative services necessary to complete the Transaction.

About Core One Labs Inc.
Core One is a biotechnology research and technology life science enterprise focused on bringing psychedelic medicines to market through novel delivery systems and psychedelic assisted psychotherapy. Core One has developed a patent-pending thin-film oral strip, which dissolves instantly when placed in the mouth and delivers organic molecules in precise quantities to the bloodstream, maintaining excellent bioavailability. The company intends to further develop and apply the technology to psychedelic compounds, such as psilocybin. Core One also holds an interest in medical clinics which maintain a combined database of over 275,000 patients. Through these clinics, the integration of its intellectual property, research and development related to psychedelic treatments, and novel drug therapies, the company intends to obtain regulatory research approval for the advancement of psychedelic-derived treatments for mental health disorders.
Core One Labs Inc.

Joel Shacker
Chief Executive Officer

FOR MORE INFORMATION, PLEASE CONTACT:
info@core1labs.com
1-866-347-5058

Cautionary Disclaimer Statement:

The Canadian Securities Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of the content of this news release.

Information set forth in this news release contains forward-looking statements that are based on assumptions as of the date of this news release. These statements reflect management’s current estimates, beliefs, intentions, and expectations. They are not guarantees of future performance. The Company cautions that all forward-looking statements are inherently uncertain, and that actual performance may be affected by a number of material factors, many of which are beyond the Company’s control. Such factors include, among other things: risks and uncertainties relating to the Company’s limited operating history and the need to comply with strict regulatory regulations. Accordingly, actual and future events, conditions and results may differ materially from the estimates, beliefs, intentions and expectations expressed or implied in the forward-looking information. Except as required under applicable securities legislation, the Company undertakes no obligation to publicly update or revise forward-looking information.

In addition, psilocybin is currently a Schedule III drug under the Controlled Drugs and Substances Act (Canada) and it is a criminal offence to possess substances under the Controlled Drugs and Substances Act (Canada) without a prescription or authorization. Health Canada has not approved psilocybin as a drug for any indication. Core One does not have any direct or indirect involvement with illegal selling, production, or distribution of psychedelic substances in jurisdictions in which it operates. While Core One believes psychedelic substances can be used to treat certain medical conditions, it does not advocate for the legalization of psychedelics substances for recreational use. Core One does not deal with psychedelic substances, except within laboratory and clinical trial settings conducted within approved regulatory frameworks.